Cytokine Blog Posts
Consuming Avocado With A Burger May Neutralize Interleukin-6

English: Pit of an avocado Deutsch: Kern einer Avocado der Sorte "Hass". (Photo credit: Wikipedia) Consuming half of a fresh Hass avocado with a burger may counteract the protein Interleukin-6 (IL-6), a measure of inflammation, compared to eating a...
by PolygenicBlog on Dec 28, 2012
ScienceDirect.com - Trends in Immunology - Drug targets in the cytokine universe for autoimmune disease

In autoimmune disease, a network of diverse cytokines is produced in association with disease susceptibility to constitute the ‘cytokine milieu’ that drives chronic inflammation. It remains elusive how cytokines interact in such a complex network...
by PolygenicBlog on Dec 18, 2012
Brain-Derived Neurotrophic Factor-Dependent Synaptic Plasticity Is Suppressed by Interleukin-1β via p38 Mitogen-Activated Protein Kinase

Evolving evidence suggests that brain inflammation and the buildup of proinflammatory cytokine increases the risk for cognitive decline and cognitive dysfunction. Interleukin-1β (IL-1β), acting via poorly understood mechanisms, appears to be a key...
by PolygenicBlog on Dec 7, 2012
Alzheimer's disease in mice alleviated promising therapeutic approach for humans

Pathological changes typical of Alzheimer's disease were significantly reduced in mice by blockade of an immune system transmitter. A research team from Charité - Universitätsmedizin Berlin and the University of Zurich has just published a new ther...
by PolygenicBlog on Nov 26, 2012
Study identifies a potential cause of Parkinson's disease

Conti and his team were looking for biological pathways that could connect the immune system's inflammatory response to the damage seen in dopaminergic neurons. After searching human genomics databases, the team's attention was caught by a gene encod...
by PolygenicBlog on Nov 20, 2012
Soluble interleukin-6 receptor induces motor stereotypies and co-localizes with gp130 in regions linked to cortico-striato-thalamo-cortical circuits.

Soluble cytokine receptors are normal constituents of body fluids that regulate peripheral cytokine and lymphoid activity and whose levels are increased in states of immune activation. Soluble interleukin-6 receptor (sIL-6R) levels positively corr...
by PolygenicBlog on Aug 23, 2012
Macrophage migration inhibitory factor mediates the antidepressant actions of voluntary exercise

Voluntary exercise is known to have an antidepressant effect. However, the underlying mechanism for this antidepressant action of exercise remains unclear, and little progress has been made in identifying genes that are directl...
by PolygenicBlog on Aug 7, 2012
Researchers pursue red flag for schizophrenia relapse

Blood levels of a protein that helps regulate inflammation ( Interleukin 6 : IL6) may also serve as a red flag for relapse in some schizophrenia patients, researchers said.pub-5799224524264318...
by PolygenicBlog on Aug 7, 2012
Hippocampal expression of murine IL-4 results in exacerbation of amyloid deposition.

Pro-inflammatory stimuli, including cytokines like Interleukin-1beta, Interleukin-6 and Interferon-gamma, in the brain have been proposed to exacerbate existing Alzheimer's disease (AD) neuropathology by increasing amyloidogenic processing of APP and...
by PolygenicBlog on Jul 31, 2012
Maternal immune activation causes age- and region-specific changes in brain cytokines in offspring throughout development.

Maternal infection is a risk factor for autism spectrum disorder (ASD) and schizophrenia (SZ). Indeed, modeling this risk factor in mice through maternal immune activation (MIA) causes ASD- and SZ-like neuropathologies and behaviors in the offspri...
by PolygenicBlog on Jul 31, 2012
Elevated interleukin-18 serum levels in chronic schizophrenia: Association with psychopathology.

Schizophrenia is associated with various abnormalities in the immune system including elevated levels of Interleukin-18 (IL-18), a potent inflammatory cytokine in T-helper 1 (Th1) responses. The aim of this study was to assess the clinical signifi...
by PolygenicBlog on Jun 3, 2012
MicrobeWorld - David and Goliath: How one cytokine may take down influenza

Image via WikipediaThe cytokine is granulocyte-macrophage colony-stimulating-factor (CSF2) which controls the production, differentiation, and function of granulocytes and macrophages. Related articlesImmunolocalization of influenza A virus and ma...
by PolygenicBlog on Oct 8, 2011
