timsandle Profile

Latest Blog Posts

• Risk Management in Pharmaceutical Microbiology
  on May 19, 2013 in Books Microbiology
   Pharmaceutical Manufacturing has published an article by Tim Sandle titled 'Risk Management in Pharmaceutical Microbiology'. The article looks at risk assessment techniques, such as HACCP and FMEA, from a microbiological perspective. "Within m...
• Cleanroom Management in Pharmaceuticals and Healthcare
  on May 18, 2013 in Books
  Cleanroom Management in Pharmaceuticals and Healthcare Edited by Tim Sandle and Madhu Raju Saghee. Everything you need to know about the operation and management of cleanrooms. In 26 Chapters and over 600 pages this book provides a unique tool to...
• Metallothioneins and fungal pathogens
  on May 18, 2013 in Antimicrobial
  Metallothioneins, proteins able to capture metal ions, play a major role in the virulence of Cryptococcus neoformans, a fungal pathogen which causes severe infections in immunodeficient and immunocompetent individuals (AIDS patients, transplant rec...
• Antibiotic resistance news
  on May 17, 2013 in antibiotics
  New scientific research published in the journal PLoS Biology shows that bacteria can evolve resistance more quickly when stronger antibiotics are used. Researchers from the University of Exeter and Kiel University in Germany treated E. coli with di...
• Guidance on disinfectants from Health Canada
  on May 16, 2013 in Disinfection Cleanrooms
  Health Canada has issued a Draft Guidance Document: Disinfectant Drugs (2013). The CDC Handbook: A Guide to Cleaning and Disinfecting Cleanrooms According to Health Canada: "This document has been created to provide a more user friendly and compr...
• FDA Releases Draft Guidance on Labeling Safety
  on May 15, 2013 in FDA Regulatory Pharmaceutical processing
  The FDA has issued the following draft guidance: "Guidance for Industry Safety Considerations for Container  Labels and Carton Labeling Design to  Minimize Medication Errors". The introduction to the document states: "The purpose of this...
• Detergent choices for endoscope reprocessing
  on May 14, 2013 in Infection Hospital
  The first stage of endoscope cleaning involves the use of detergents. Without adequate cleaning, the disinfection stage will not be completed successfully and the risk of microbial survival becomes greater. There are two classes of detergent: enzymat...
• What is an antimicrobial stewardship programme (ASP)?
  on May 13, 2013 in antibiotics
  Optimisation of antimicrobial use is the overriding goal of any antimicrobial stewardship programme (ASP). Ultimately, it is about finding the balance between effective use and overuse – equating to managing proper selection, duration, dose, and ro...
• Cleaning endoscopes
  on May 12, 2013 in Infection Hospital
  The cleaning of endoscopes is an important part of contamination control in hospitals and in avoiding the transmission of hospital acquired infections. Cleaning involves the use of detergents. The selection of detergents is an important one, with the...
• Education resource for schools - Marvellous Microbes
  on May 11, 2013 in Microbiology Education
  The Society for General Microbiology has issued an educational resource for schools called “Marvellous Microbes - A visit to the dentist (Issue 3)”. In this issue of Marvellous Microbes a boy, curious to know why he needs to brush and floss hi...
• Hand Hygiene among Microbiological Laboratory Workers
  on May 10, 2013 in Infection Hospital
  An article by Popovska et al has been published by the Macedonian Journal of Medical Sciences. The article presents the experience of laboratorians in the Microbiology Department in the Clinical Center in Skopje in promoting proper hand hygiene by pa...
• Detergents and disinfectants
  on May 9, 2013 in Disinfection
  Detergents and disinfectants for use on cleanroom surfaces (walls, floors) must be applied using the double or triple-bucket system to avoid cross contamination. Both of these techniques involve using a bucket of disinfectant and a bucket of water. I...
• Gamma irradiation cleans up
  on May 8, 2013
  In a free to view article, Tim Sandle and Madhu Raju Saghee (editors of the book Cleanroom Management), explore how gamma radiation can be used for the sterilization of medical devices. Here is a summary of the article: "Gamma rays f...
• Tackling water polution
  on May 7, 2013 in Pollution Bacteria
  Water pollution, especially the waste from the beverage and pharmaceutical industry  is becoming an issue of global concern. One way to address this is through the use of bacteria. Scientists have genetically engineered...
• Cleanrooms and hospitals
  on May 6, 2013
  “Cleanrooms and clean zones are found in two important areas within the hospital setting: in operating theatres and within hospital pharmacy units. These clean areas are designed to minimise and control the level of airborne particulates… There i...
• Combinatorial discovery of polymers resistant to bacterial attachment
  on May 5, 2013 in Bacteria
  An interesting article on a new class of polymers (a group of structurally related materials comprising ester and cyclic hydrocarbon moieties) that are resistant to bacterial attachment has been published by Nature Biotechnology. Here is the referenc...
• Studying Pharmaceutical Microbiology
  on May 5, 2013 in Courses
  The University of Manchester have updated the different modules that can be taken as either stand-alone modules or as a series of a Master's degree in Pharmaceutical Microbiology. The modules are: MODULE 1 Introduction to Pharmaceutical Microbiolo...
• Microbial Risk Assessment (MRA) Guideline Published
  on May 4, 2013 in Health and safety
  The U.S. Department of Agriculture's Food Safety and Inspection Service (FSIS) and the Environmental Protection Agency (EPA) have unveiled a new tool that will help scientists improve the quality of data collected and used to protect consumers from p...
• Toward a Revised International Cleanroom Standard
  on May 3, 2013 in ISO Cleanrooms
  Dr Tim Sandle has written an article for Controlled Environments titled “Toward a Revised International Cleanroom Standard”. The introduction to the article reads: “A proposed new version of the international cleanroom standard ISO 14644...
• Cleanroom Flooring
  on May 2, 2013
  A study of particles and cleanroom flooring revealed that the levels of particles removed from footwear and retained on the flooring were highest for the polymeric flooring when compared with a range of different adhesive mats. A further risk aris...

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